人造甜味剂会导致健康的肠道细菌具致病性
新的研究显示，多种盛行于市面的人造甜味剂，如：糖精、蔗糖素和阿斯巴甜等代糖，会导致原本健康的肠道细菌演变为具致病性。
在相当于两罐代糖软性饮料的浓度下，人造甜味剂会造成：
• 肠道细菌入侵并破坏肠道，增加肠道感染、败血症和多重器官衰竭的发生风险，以及
• 生物膜的增生，从而导致更多的毒素分泌和更高的抗生素耐药性。
Artificial Sweeteners Can Cause Healthy Gut Bacteria to Become Pathogenic
New research shows that popular artificial sweeteners, such as saccharin, sucralose, and aspartame, can cause healthy gut bacteria to become pathogenic.
At a concentration equivalent to two cans of diet soft drink, the artificial sweeteners can lead to:
* gut bacteria invading and damaging the intestine, increasing the risk of infection, sepsis, and multiple-organ failure, and
* the increased formation of biofilms, which leads to more toxins secreted and greater antibiotic resistance.
Note:
Artificial sweeteners (AS) are synthetic sugar substitutes that are commonly consumed in the diet. Recent studies have indicated considerable health risks which links the consumption of AS with metabolic derangements and gut microbiota perturbations. Findings show that sweeteners differentially increase the ability of bacteria to form a biofilm. Co-culture with human intestinal epithelial cells shows an increase in the ability of model gut bacteria to adhere to, invade and kill the host epithelium.
Source:
MDPI https://www.mdpi.com/about
MDPI is a publisher of peer-reviewed, open access journals since its establishment in 1996.
Related Topic
人造甜味剂结合碳水化合物的饮食会导致健康风险
Artificial Sweeteners Plus Carbs Can Lead to Health Risks
A study of more than 100,000 people has found that artificial sweeteners may be associated with an increased risk of cancer. Researchers found that compared to the group of people who consumed no artificial sweeteners, those who consumed larger amounts of artificial sweeteners, particularly aspartame and acesulfame-K, had an increased overall cancer risk.
一项针对超过十万人的研究发现，人造甜味剂可能和罹患癌症风险的增加之间存在关联。研究人员发现，相较于不摄取人造甜味剂的人群，大量摄取人造甜味剂（尤其是阿斯巴甜和安赛蜜/醋磺內酯钾）的人群总体上癌症的罹患风险更高。
March 2022
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003950
